Affinity and Efficacy:The Components of Drug-Receptor by Frederick J Ehlert PDF

By Frederick J Ehlert

The interplay of a drug with a receptor generates a code of data having elements of affinity and efficacy. How this knowledge is translated right into a reaction is determined by the original cells, tissue, organ or method within which the receptor is living. This booklet describes the right way to learn numerous responses to estimate the affinity and efficacy parts of the preliminary drug–receptor interplay. extra in particular, it describes find out how to degree the affinity and efficacy of substances in the course of the research of unmarried receptor task, the activation country of a inhabitants of receptors, and responses downstream from receptor activation. extra gentle is thrown on ligand-gated ion channels and G protein-coupled receptors during this book.

The subject matters mentioned comprise radioligand binding, estimation of agonist affinity and efficacy, aggressive antagonism, inverse agonism, allosteric agonists and modulators, agonist bias, modulation of pathway selectivity, and the estimation of ligand affinity for lively and inactive receptor states. The typical heritage and constitution of ligand-gated ion channels, G proteins, and G protein-coupled receptors also are discussed.

Show description

Read or Download Affinity and Efficacy:The Components of Drug-Receptor Interactions PDF

Similar pharmacology books

Antiviral Agents (Advances in Pharmacology) by Erik De Clercq PDF

This new quantity of Advances in Pharmacology explores the present kingdom of antiviral brokers. Chapters hide such subject matters as virus access inhibitors, interferon-free drug combos, and antiviral brokers for HSV. With numerous chapters and the easiest authors within the box, the quantity is a necessary source for pharmacologists, immunologists and biochemists alike.

Histamine Intolerance: Histamine and Seasickness by Reinhart Jarisch PDF

Histamine is a crucial mediator of allergic ailments, yet wisdom of histamine as a reason behind a variety of non-allergic signs and symptoms is restricted. This publication bargains wide-ranging assurance of histamine intolerance. there's large history dialogue of the beginning of histamine, its content material in nutrients and alcoholic drinks and intolerance to purple wine.

Download e-book for iPad: Textbook of Interventional Cardiovascular Pharmacology by Nicolas Kipshidze,Jawad Fareed,Patrick W. Serruys,Jeff Moses

Whereas all interventional cardiologists have entry to pharmacopeial texts and databases and are conscious of the growing to be variety of pharmacological brokers within the armamentarium, questions come up as to the correct agent or blend of brokers in differing sufferer occasions. This wonderful textual content bargains the reader insurance of the entire significant pharmacological remedies utilized in treating the cath lab sufferer from the sensible, own viewpoint of these actively fascinated by interventional cardiology.

Arzneimitteltherapie in der Palliativmedizin (German by Claudia Bausewein,Constanze Rémi,Robert Twycross,Andrew PDF

  Palliativmedizinisches Arzneimittelwissen – kompetent und praxisnah Nach über 10 Jahren jetzt die 2. Auflage mit aktuellen, umfassende Informationen zu allen praxisrelevanten Medikamenten im Bereich der Palliativmedizin. Detaillierte Arzneimittelmonografien, nach Organsystemen und Einsatzbereichen geordnetAusführliche Informationen zu Sonderfällen in der Palliativmedizin wie z.

Extra resources for Affinity and Efficacy:The Components of Drug-Receptor Interactions

Example text

Download PDF sample

Affinity and Efficacy:The Components of Drug-Receptor Interactions by Frederick J Ehlert


by Richard
4.0

Rated 4.13 of 5 – based on 32 votes