Read e-book online Chemokine Receptors as Drug Targets, Volume 46 (Methods and PDF

By Martine J. Smit,Sergio A. Lira,Rob Leurs

Chemokines are hormone-like signaling molecules secreted by way of cells to sign an infection and advisor the immune reaction. Following a decade of uncomplicated chemokine learn, the pharmaceutical has now began to use this significant signaling pathway for the improvement of leading edge medications opposed to AIDS, melanoma, neural and autoimmune ailments. here's the 1st reference targeting those novel drug improvement opportunities.
establishing with a basic advent on chemokine functionality and chemokine receptor biology, the second one half covers the identified implications of those signaling molecules in human illnesses, corresponding to melanoma, neural issues, and viral an infection, together with AIDS. The 3rd half systematically surveys present drug improvement efforts at concentrating on person chemokine receptors, in addition to different chemokine interplay companions, together with up to date experiences from the pharmaceutical industry.

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Chemokine Receptors as Drug Targets, Volume 46 (Methods and Principles in Medicinal Chemistry) by Martine J. Smit,Sergio A. Lira,Rob Leurs

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