By Amy M. Fulton
Chemokines are a superfamily of low molecular weight cytokines that have been before everything defined in response to their skill to urge the directed migration of leukocytes to websites of irritation or damage. In people, there are nearly forty five chemokines that bind to 19 G-protein-coupled receptors. as well as mediating mobile migration, chemokines have now been proven to impact many mobile services together with survival, adhesion, invasion, proliferation, and to manage circulating chemokine degrees. even supposing chemokine receptors have been first defined on leukocytes, it truly is now liked that chemokine receptors also are expressed by way of many different cells together with endothelial and epithelial cells.
Since the 1st description of chemokine receptors on malignant cells in 2001, an intensive literature has built describing the expression and serve as of chemokine receptors in lots of malignancies. those stories help the preliminary speculation that malignant cells use chemokine receptors emigrate to far-off websites of ligand expression and that expression of sure receptors is linked to a bad analysis. It has additionally develop into obvious that malignancies of alternative tissues may possibly use a various profile of chemokine receptors and that a similar receptor may well mediate metastasis to various websites in tumors of other histological origins. Receptor functionality can also hold survival and growth of the first tumor.
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Additional resources for Chemokine Receptors in Cancer (Cancer Drug Discovery and Development)
Chemokine Receptors in Cancer (Cancer Drug Discovery and Development) by Amy M. Fulton